Authors
- Tkachev Alexander Vladimirovich Doctor of International Veterinary Academy, Senior Researcher
- Tkacheva Olga Leonidovna Candidate of Agricultural Sciences
Annotation
The relevance of the study is due to the fact that herpes simplex can deplete the immune system of patients, causing an immunodeficiency disorder, and create conditions
for the activation of infections. Herpes simplex can deplete the immune system of patients, causing an immunodeficiency disorder, and create conditions for the activation of infections. And on the other hand — to cause polyclonal excitation of cytotoxic lymphocytes, supporting autoimmune inflammation. These relationships in the conditions of psoriasis and combined herpesvirus simplex infection have not been studied enough. The aim of the study: to compare the active replication of herpes simplex viruses of 1/2 types, the synthesis of miR-155 and miR-146a molecules by blood cells in patients with psoriasis, patients with recurrent HSV-1/2 during the year, patients with Psoriasis and HSV-1/2 and healthy individuals. The research was conducted on the basis of the Skin and Venereological Dispensary from 2015 to 2023. The study included 37 patients with HSV-1/2; 45 patients with Psoriasis and HSV-1/2; 38 patients with Psoriasis alone and 26 clinically healthy individuals without chronic diseases who had not been vaccinated and prescribed immunotropic drugs during the last month. The expression of miRNA-146a and miRNA-155 in blood serum was
determined by polymerase chain reaction. It was found that the most pronounced expression of activating anti-inflammatory molecules miR-155 was observed in the group of patients with Psoriasis and HSV-1/2, which is more from healthy individuals by 113 U/6 (P < 0.001), more from patients only HSV-1/2 by 62.9 U/6 (P < 0.001), more from patients only psoriasis at 24.9 U/6 (P < 0.001). At the same time, the expression of activation inhibitory miR-146a was the lowest in patients with Psoriasis and HSV-1/2, which was less from healthy individuals by 0.51 U/6 (P < 0.001), less from patients with HSV 1,2 only by 0.4 U/6 (P < 0.01), less from patients with psoriasis only by 0.11 U/6 (P < 0.05).
How to link insert
Tkachev, A. V. & Tkacheva, O. L. (2924). MOLECULAR GENETIC FEATURES IN PATIENTS WITH PSORIASIS WITH ACTIVATED CHRONIC HERPESVIRUS SIMPLEX INFECTION Bulletin of the Moscow City Pedagogical University. Series "Pedagogy and Psychology", № 3 (55), 62. https://doi.org/10.25688/2076-9091.2024.55.3.05
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