Authors
- Bobkova Sofya Niazovna Associate Professor, Candidate of Medical Sciences
- Bobkov German Sergeevich
- Zvereva Marina Valentinovna Associate Professor, Candidate of Medical Sciences
Annotation
The relevance of this study is due to the high mortality rate among people of working age from cardiovascular diseases. The use of diagnostic markers and adaptogens
can be effective in the early stages of coronary atherosclerosis. The aim of the study was to evaluate the effect of the atherosclerotic process and the adaptogen oxy-ethylammonium methylphenoxyacetate on the activity of acid lipase in monocytes and platelets in dyslipidemia. The article examines the effect of the adaptogen on the activity of the lysosomal enzyme acid lipase in blood cells (monocytes and platelets) and the level of serum lipids in dyslipidemia. Enzyme activity was determined by spectrophotometric method; serum lipids by enzymatic colorimetric method. The study involved 77 men aged 37 ± 4,6 years with lipid metabolism disorders dyslipidemia). All study participants were examined to identify risk factors for cardiovascular complications. More than half of the men had 2 or more of these risk factors. The participants of the control and experimental groups adhered to the recommendations on the content of the diet and physical activity. For one month, 40 people in the experimental group took trecresan (600 mg per day). The initial assessment of the level of acid lipase activity of lysosomes in platelets and monocytes in dyslipidemia
in men of the control and experimental groups showed its decrease compared to the norm, which indicated the activity of the atherosclerotic process. Adaptogen intake
caused a significant (p < 0,05) increase in the level of enzyme activity in blood cells in men of the experimental group: in platelets by 32 %, and in monocytes by 30,1 %, and a decrease in the level of atherogenic lipids by 12–35 % and an increase in high-density lipoprotein cholesterol by 15,5 %, which indicates the hypolipidemic effect of oxy-ethylammonium methylphenoxyacetate, and acid lipase can be considered as a marker of atherosclerosis activity.
How to link insert
Bobkova, S. N., Bobkov, G. S. & Zvereva, M. V. (2021). The effect of oxy-ethylammonium methylphenoxyacetate on the activity of cholesterol esterase in lipid metabolism disorders Bulletin of the Moscow City Pedagogical University. Series "Pedagogy and Psychology", 2021, №4 (44), 6. https://doi.org/10.25688/2076-9091.2021.44.4.1
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