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Native and synthetic ligands for G-quadruplexes

Biological Sciences , UDC: 577.1 DOI: 10.25688/2076-9091.2021.44.4.2

Authors

  • Lizunova Sofya Aleksandrovna
  • Vedekhina Tatyana Sergeevna Candidate of Chemical Sciences, Candidate of Chemical Sciences
  • Varizhuk Anna Mikhailovna Doctor of Chemical Sciences, Doctor of Chemical Sciences

Annotation

G-quadruplex (G4) is a well-known secondary nucleic acid structure containing guanine-rich sequences, and plays a significant role in pharmacological and biological phenomena associated with oncological diseases. Thus, G4 ligands are receiving a lot of attention as potential therapeutic agents. To date, a large number of DNA/RNA G4 ligands have been developed in several laboratories. The use of G4 ligands in medical practice is hindered mainly by their toxicity and low selectivity. This low selectivity can cause undesired effects, resulting in clinical trial cancellation. In this review, we refer to recent studies of natural and synthetic ligands interacting with quadruplexes. Macrocyclic compounds (telomestatin derivatives and porphyrins), natural condensed heterocyclic compounds (indoles, indolysins, berberines, flavonoids and phenoxazines), synthetic derivatives (acridines, quinazolones and quinolines, phenanthrolines and anthraquinones), modular ligands and metal complexes are considered as G4-targeting therapeutic agents.
Tags:
G-quadruplex , G4-selective ligands , native compounds

How to link insert

Lizunova, S. A., Vedekhina, T. S. & Varizhuk, A. M. (2021). Native and synthetic ligands for G-quadruplexes Bulletin of the Moscow City Pedagogical University. Series "Pedagogy and Psychology", 2021, №4 (44), 16. https://doi.org/10.25688/2076-9091.2021.44.4.2
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