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Природные и синтетические лиганды к G-квадруплексам

Биологические науки , УДК: 577.1 DOI: 10.25688/2076-9091.2021.44.4.2

Авторы

  • Лизунова Софья Александровна
  • Ведехина Татьяна Сергеевна кандидат химических наук, кандидат химических наук
  • Варижук Анна Михайловна ведущий научный сотрудник, доктор химических наук

Аннотация

G-квадруплекс (G4) представляет собой известную вторичную структуру нуклеиновой кислоты, содержащую богатые гуанином последовательности. Такие структуры – значимый объект в молекулярной биологии и биохимии, ввиду их связи с развитием онкологических заболеваний. Они представляют интерес в фармакологии как мишени терапевтических агентов (лигандов). На сегодняшний день в ряде лабораторий разработано большое количество G4-лигандов ДНК/РНК. Применению G4-лигандов в медицинской̆ практике препятствуют, главным образом, их низкая селективность и токсичность. Такая низкая селективность может вызвать неожиданные эффекты, которые обычно являются причиной остановки процесса разработки лекарств. Этот обзор направлен на недавние исследования природных и синтетических лигандов, взаимодействующих с квадруплексами. В числе G4-направленных терапевтических агентов рассмотрены макроциклические соединения (производные теломестатина и порфирины), природные конденсированные гетероциклические соединения (индолы, индолизины, берберины, флавоноиды и феноксазины) и их синтетические производные (акридины, хиназолоны и хинолины, фенантролины и антрахиноны), модульные лиганды и металлокомплексы.
Ключевые слова
G-квадруплекс; селективные G4-лиганды , природные соединения.

Как ссылаться

Лизунова, С. А., Ведехина, Т. С. & Варижук, А. М. (2021). Природные и синтетические лиганды к G-квадруплексам Вестник МГПУ «Естественные науки», 2021, №4 (44), 16-41. https://doi.org/10.25688/2076-9091.2021.44.4.2
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